The analysis of concentrations of circulating antibodies in serum (antibody repertoire) is a fundamental problem in immunoinformatics. Antibodies are not directly encoded in germline but are extensively diversified by somatic gene recombination and mutations. These processes complicate analysis of the original repertoire from sequencing data. On the other hand, antibody repertoire is custom for each individual that results in a lack of gold standard test datasets. In order to address these challenges, we are developing a novel toolkit for various manipulations with sequencing data including algorithms for antibody repertoire construction, instruments for clonal and statistical analysis, quality assessment and simulation tools.

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